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And 2) damage to the oligodendrocyte exerted by inflammatory molecules, brain resident cells, such as oligodendrocytes, astrocytes, and microglia or peripheral immune cells – neutrophils or T-cells

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Another real-world study of application of an 8% capsaicin patch in 57 patients who were experiencing painful CIPN reported that 44% had important or complete pain relief with few side effects, although the patch was less effective for those who had received platinum-based therapy (Bienfait 2023)