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Under basal conditions, Kelch-like ECH-associated protein 1 (Keap1), an adaptor protein for the Cullin3-containing E3 ubiquitin ligase complex, binds to Nrf2 and targets it for ubiquitin-mediated proteasomal degradation, thereby suppressing antioxidant gene expression and sequestering Nrf2 in the cytoplasm [84]
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Styles:GC19 - 16 mm, Full, Asymmetric, Multi-layered
doi: 10.1084/jem.20042299
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