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Copper and vitamin C can sometimes reduce each other's effectiveness if applied together, so many people use them at different times of day Retinol and GHK-Cu are often used on alternating nights to reduce irritation risk Sunscreen should always be the last step in a morning routine, regardless of other actives Layering too many active ingredients at once increases the risk of redness and sensitivity If your skin reacts poorly to a new combination, stop and consult a clinician